GSK575594A is a modulator of the nicotinic acetylcholine receptor ( nAChR ) in Ascaris suum . GSK575594A enhances muscle contractions induced by acetylcholine (ACh) by binding to the allosteric binding site between subunits within the transmembrane domain of nAChR . At a concentration of 3 μM, GSK575594A significantly increased the contraction induced by ACh in Ascaris suum ( E max increased from 1.19 g to 1.51 g). GSK575594A may be used in research within the field of antiparasitic studies.
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