2-Hydroxy-6-(2-(naphthalen-2-yl)ethyl)benzoic acid

Overview

Sm4 is a selective and orally active SOX18 inhibitor. Sm4 inhibits SOX18-DNA binding ( IC 50 = 97.5 μM); Sm4 disrupts the SOX18-RBPJ protein-protein interaction ( IC 50 = 42.3 μM). Sm4 blocks SOX18 DNA binding, disrupts multiple SOX18 protein-protein interactions with RBPJ , DDX1 , DDX17 , ILF3 , SOX7 and STAT1 , modulates SOX18 chromatin binding dynamics. Sm4 exerts anti‑angiogenic and anti‑lymphangiogenic effects, reduces tumor vascular density, triggers vascular defects in zebrafish, prolongs survival in mouse metastatic cancer models. Sm4 can be used for the research of breast cancer .

Application

Products

Product Information

• Catalog No.: BP-29545
• CAS No.: 365542-77-4
• Molecular Formula: C19H16O3
• Molecular Weight: 292.33
• Purity: 95%
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source