JK-184

Overview

JK-184 is a potent downstream hedgehog (Hh) signaling antagonist that functions by alcohol dehydrogenase 7 (Adh7) inhibition, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). Hedgehog signaling plays a key role in a wide variety of developmental processes as well as cancer progression. JK-184 exhibits antiproliferative activity.

Application

Products > Drug Discovery > Inhibitor | Products > Drug Discovery > Inhibitor | Neurological Disease | Hedgehog

Product Information

• Catalog No.: B2693-462944
• CAS No.: 315703-52-7
• Molecular Formula: C19H18N4OS
• Molecular Weight: 350.44
• Purity: 98%

Source

Original product source