GQ-16

Overview

GQ-16 is an orally active PPARγ partial agonist with an IC 50 of 1.84 μM and a K i of 160 nM against human PPARγ . GQ-16 inhibits Cdk5-mediated Ser-273 phosphorylation. GQ-16 improves insulin sensitivity and glucose tolerance in obese and diabetic mice. GQ-16 also exhibits certain cytotoxicity against tumor cells. GQ-16 can be used in research related to obesity, diabetes and cancer .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-111254
• CAS No.: 870554-67-9
• Molecular Formula: C19H16BrNO3S
• Molecular Weight: 418.30
• Purity: 98.12%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (2.39 mM); Clear solution
• Availability: In-stock

Source

Original product source