BMP-22

Overview

BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.

Application

PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Phospholipid | Drug Delivery, Surface Modification > Lipid Molecules > Phospholipid | Products > Lipids In Drug Delivery > Phospholipid | Products > Lipids In Drug Delivery > Phospholipid > Phosphate

Product Information

• Catalog No.: BP-43103
• CAS No.: 1306684-90-1
• Molecular Formula: C22H39O3P
• Molecular Weight: 382.5
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source