PFI 1

Overview

PFI 1 is a BET bromodomain inhibitor that exhibits inhibitory activity at BRD2 and BRD4. PFI-1 is a selective BET bromodomain inhibitor with activity at BRD2 (IC50 = 98 nM) and BRD4 (IC50 = 220 nM). PFI 1 induces apoptosis and G1 cell cycle arrest in BET inhibitor-sensitive cell lines (MV4;11). PFI 1 also downregulates Aurora B expression in MV4;11 cells. Please contact us for GMP-grade inquiries.

Application

Products > PROTAC, Molecular glue > Inhibitors

Product Information

• Catalog No.: BP-25371
• CAS No.: 1403764-72-6
• Molecular Formula: C16H17N3O4S
• Molecular Weight: 347.4
• Storage: -20°C
• Availability: In Stock

Source

Original product source