VHL Ligand 8

Overview

VHL Ligand 8 is a small molecule ligand for the VHL E3 ligase, serving as a key component in the synthesis of ARD-266, a potent PROTAC degrader targeting the androgen receptor (AR). ARD-266 facilitates AR degradation in specific cell lines, with a high degree of efficiency, indicated by DC50 values ranging from 0.2 to 1 nM. This highlights the usefulness of VHL Ligand 8 in developing targeted protein degradation tools. Reagent-grade; for laboratory research purposes only.

Application

Products > PROTAC, Molecular glue > Ligands

Product Information

• Catalog No.: BP-42114
• CAS No.: 2701565-76-4
• Molecular Formula: C23H29N3O6
• Molecular Weight: 443.5
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source