Boc-PEG2-Val-Cit-PAB-OH

Overview

Boc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

Application

Products > PEG Linkers > GGFG Linkers | Products > ADC Linker, ADC Payload > Cleavable Linkers > Val-Cit

Product Information

• Catalog No.: BP-23215
• CAS No.: 2055024-55-8
• Molecular Formula: C30H50N6O9
• Molecular Weight: 638.8
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source