Bis-sulfone-PEG12-NHS Ester (CAS: 2055105-51-4) is a versatile reagent for bioconjugation and protein crosslinking . It works by selectively targeting cysteine thiols from disulfide bonds, forming stable thioether bridges while maintaining protein structure. This makes it ideal for PEGylation and biopharmaceutical development , as it both improves protein stability and solubility without affecting its natural function.
Polyethylene Glycol PEG Linkers > Bis-Sulfone PEG > Bis-sulfone NHS Ester
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