(S)-C12-200 (solution in ethanol)

Overview

(S)-C12-200 is an ionizable cationic lipid (pKa = 7.12) and an isomer of C12-200, used in the formulation of lipid nanoparticles (LNPs) for in vivo mRNA delivery. Intravenous administration of LNPs formulated with (S)-C12-200 and encapsulating mRNA encoding Cre recombinase results in a higher percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the livers of Ai14 mice compared to LNPs containing (R)-C12-200 with Cre mRNA.

Application

PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Ionizable Lipid | PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Branched Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Ionizable Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Branched Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid > Multi chargeable lipid | Products > Lipids In Drug Delivery > Branched Lipid > Branched Lipid

Product Information

• Catalog No.: BP-42679
• CAS No.: 1226552-44-8
• Molecular Formula: C70H145N5O5
• Molecular Weight: 1137
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source