JB170

Overview

JB170 is a highly specific PROTAC degrader of AURORA-A, created by connecting Alisertib to a Cereblon-binding molecule, Thalidomide. This compound selectively binds to AURORA-A, demonstrating a strong preference over AURORA-B. JB170 effectively induces S-phase arrest through targeted AURORA-A depletion, while also inhibiting its non-catalytic functions. Reagent-grade; for laboratory research purposes only.

Application

Products > PROTAC, Molecular glue > Degraders

Product Information

• Catalog No.: BP-42263
• CAS No.: 2705844-82-0
• Molecular Formula: C48H44ClFN8O11
• Molecular Weight: 963.4
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source