VL422 (solution in methyl acetate)

Overview

VL422 is an ionizable cationic lipid employed in the development of lipid nanoparticles (LNPs) for delivering CRISPR single-guide RNA (sgRNA) and Cas9 mRNA for gene editing both in vitro and in vivo. LNPs formulated with VL422 and encapsulating Cas9 mRNA and sgRNA targeting the gene for angiopoietin-related protein 3 (ANGPTL3) induce the deletion of a premature stop codon in ANGPTL3 in the livers of cynomolgus monkeys. Loss-of-function of ANGPTL3 is associated with reduced plasma levels of LDL, HDL, and cholesterol.

Application

PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Ionizable Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Ionizable Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid > LP01 & Analogs

Product Information

• Catalog No.: BP-42687
• CAS No.: 2765519-47-7
• Molecular Formula: C62H117NO11
• Molecular Weight: 1052.6
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source