Si5-N14 (solution in ethanol)

Overview

Si5-N14 is a siloxane-incorporated ionizable cationic lipidoid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA and single-guide RNA (sgRNA) in vitro and in vivo. LNPs containing Si5-N14 and encapsulating a luciferase mRNA reporter exhibit increased cellular uptake via micropinocytosis and lipid raft-mediated endocytosis pathways and endosomal escape compared with LNPs containing non-siloxane-incorporated lipids in immortalized human lung microvascular endothelial cells (iMVECs).

Application

PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Ionizable Lipid | PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Branched Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Ionizable Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Branched Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid > Multi chargeable lipid | Products > Lipids In Drug Delivery > Branched Lipid > Branched Lipid

Product Information

• Catalog No.: BP-45537
• CAS No.: 3006860-57-4
• Molecular Formula: C78H160N6O5Si2
• Molecular Weight: 1318.4
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source