Leupeptin hydrochloride

Overview

Leupeptin hydrochloride is a broad-spectrum protease inhibitor. Leupeptin hydrochloride inhibits serine, cysteine and threonine proteases, and regulates autophagy . Leupeptin hydrochloride reduces the expression levels of LC3B , iNOS , Cox-2 , Beclin-1 and the level of endopeptidases; increases the levels of p62 , Arg 1 , Msr 1 and Mrc − 1 ; and blocks the upregulation of p-PTEN , p-NF-κB , p-PI3K , p-Akt , p-p38 and ERK1/2 . Leupeptin hydrochloride inhibits NO, ROS , proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux . Leupeptin hydrochloride is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections.

Application

Products | Products > Peptides | Products > Disease Areas > Infection | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Skin Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Signaling Pathways > Ser/Thr Protease | Products > Signaling Pathways > Cathepsin | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > SARS-CoV | Products > Signaling Pathways > Atg8/LC3 | Products > Signaling Pathways > NO Synthase | Products > Signaling Pathways > COX | Products > Signaling Pathways > p62 | Products > Signaling Pathways > Arginase | Products > Signaling Pathways > PTEN | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > ERK | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-183478
• CAS No.: 39740-82-4
• Molecular Formula: C20H39ClN6O4
• Molecular Weight: 463.01
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source