6-O-Methyl Guanosine

Overview

6-O-Methyl Guanosine is a Ribonucleoside . Replacement of the conserved G5, G8 or G12 residues in hammerhead ribozymes with 6-O-Methyl Guanosine reduces k cat without altering K m . 6-O-Methyl Guanosine exerts position-dependent regulatory effects on ribosomal velocity and fidelity. When 6-O-Methyl Guanosine is located at the first or third position of a codon, it decreases the accuracy of tRNA selection. When 6-O-Methyl Guanosine is located at the second position of a codon, it slows down the peptide bond formation rate of cognate aminoacyl-tRNA but does not change the reaction rate of near-cognate aminoacyl-tRNA.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Others | Products > Signaling Pathways > Nucleoside Antimetabolite/Analog

Product Information

• Catalog No.: HY-111648
• CAS No.: 7803-88-5
• Molecular Formula: C11H15N5O5
• Molecular Weight: 297.27
• Purity: 99.65%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 6.5 mg/mL (21.87 mM); Clear solution
• Availability: In-stock

Source

Original product source