SKA-31 is a potent potassium channel activator with EC 50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1 , KCa2.2 , KCa2.1 and KCa2.3 , respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure.
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