(R)-Elexacaftor

Overview

(R)-Elexacaftor ((R)-VX-445) is the enantiomer of Elexacaftor ( HY-111772 ). Elexacaftor is an orally active CFTR modulator that targets nucleotide-binding domain 1. Elexacaftor stabilizes misfolded F508del-CFTR protein, enhances its trafficking to the plasma membrane, and significantly improves metabolic stability, thermal stability and ion conductivity. Elexacaftor not only restores chloride transport function in nasal epithelial cells and rescues multiple CFTR mutation subtypes, but also exerts multiplicative synergistic effects with Ivacaftor ( HY-13017 ), and is often used in a triple combination therapy with Tezacaftor ( HY-15448 ). Elexacaftor is widely used in basic and clinical translational research on cystic fibrosis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Drug Isomer | Products > Signaling Pathways > CFTR

Product Information

• Catalog No.: HY-111772A
• CAS No.: 2229860-99-3
• Molecular Formula: C26H34F3N7O4S
• Molecular Weight: 597.65
• Purity: 99.44%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (3.48 mM); Clear solution
• Availability: In-stock

Source

Original product source