1,2,3,6-Tetragalloylglucose

Overview

1,2,3,6-Tetragalloylglucose (TEgG) is a competitive inhibitor of UDP-glucuronyltransferase UGT1A1 , targeting the competitive substrate binding site of UGT1A1. 1,2,3,6-Tetragalloylglucose inhibits UGT1A1-mediated β-estradiol 3-glucuronidation and SN-38 glucuronidation with IC 50 of 6.01 μM and 4.31 μM, respectively, and binds to UGT1A1 with K i of 3.55 μM. 1,2,3,6-Tetragalloylglucose also induces tumor cell apoptosis , inhibit cell proliferation, activates caspase-3 and induces DNA fragmentation in HL-60 cells. 1,2,3,6-Tetragalloylglucose also inhibits HIV integrase and reverse transcriptase , and inhibits HCV protease .

Application

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Product Information

• Catalog No.: HY-111832
• CAS No.: 79886-50-3
• Molecular Formula: C34H28O22
• Molecular Weight: 788.57
• Purity: 99.08%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 2.5 mg/mL (3.17 mM); Clear solution
• Availability: In-stock

Source

Original product source