6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide

Overview

6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-N-(4-(6-methyl-1,2,4,5-tetrazin-3-yl)benzyl)hexanamide is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a methyltetrazine. Thalidomide is a ligand for E3 ligase, which marks proteins for proteolysis. Meanwhile, the methyltetrazine is a click chemistry handle used to form bonds with TCO groups on target molecules.

Application

PROTAC > PROTAC Linkers > PROTAC Linkers | Products > PROTAC, Molecular glue > PROTAC Linkers | Products > PROTAC, Molecular glue > PROTAC Linkers > Thalidomide-O-methyltetrazine | Products > PROTAC, Molecular glue > PROTAC Linkers > Thalidomide-O-methyltetrazine

Product Information

• Catalog No.: BP-40569
• CAS No.: 2087490-42-2
• Molecular Formula: C29H29N7O6
• Molecular Weight: 571.6
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source