PROTAC RIPK degrader-6 (example 1) is a Cereblon -based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder. (Pink: RIPK2 ligand ( HY-184890 ); Blue: Cereblon ligand ( HY-A0003 ); Black: linker).
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