A heterobifunctional PEG linker with an azide for click chemistry and a t-butyl ester–protected acid for orthogonal conjugation. The PEG4 spacer specifically improves solubility and flexibility for efficient, stepwise bioconjugation.
Polyethylene Glycol PEG Linkers > Azide PEG > Azido-PEG-CH2CO2-tBu
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