Lipid C2

Overview

Lipid C2 is an ionizable cationic lipid employed in the development of lipid nanoparticles (LNPs) for in vivo mRNA delivery. In mice, LNPs containing lipid C2 and an mRNA reporter selectively accumulate in the liver and spleen, avoiding significant distribution to the heart, lungs, or kidneys. In a CT26 murine EBV-infected colon cancer model, LNPs with lipid C2 and mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), combined with an anti-PD-1 antibody, effectively reduce tumor volume, reverse T cell exhaustion, increase CD3+CD8+ central and effector memory T cells, and lower the proportion of CD3+ T cells expressing Pd-1 in the spleen.

Application

PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Ionizable Lipid | PEGylation of Protein, Peptide & Oligo > Lipid Molecules > Branched Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Ionizable Lipid | Drug Delivery, Surface Modification > Lipid Molecules > Branched Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid | Products > Lipids In Drug Delivery > Ionizable Lipid > Multi chargeable lipid | Products > Lipids In Drug Delivery > Branched Lipid > Branched Lipid

Product Information

• Catalog No.: BP-42681
• CAS No.: 3003022-09-8
• Molecular Formula: C70H142N6O6
• Molecular Weight: 1163.9
• Storage: -20°C
• Availability: In Stock

Source

Original product source