8-Bromo-2'-deoxyguanosine

Overview

8-Bromo-2'-deoxyguanosine is an inflammation-related DNA halogenated adduct and an early biomarker of inflammation-induced oxidative tissue damage. The formation of 8-Bromo-2'-deoxyguanosine precedes that of oxidative and nitrative products, and it can be generated via the MPO-H 2 O 2 -Cl - -Br - system. 8-Bromo-2'-deoxyguanosine serves as the immunogen for preparing the monoclonal antibody mAb8B3, which can be used to detect early DNA modifications in preclinical models; its urinary level also increases significantly in inflammatory disease models. 8-Bromo-2'-deoxyguanosine can also be produced in the dermis of UV-B irradiated mice, and the extract of Coprinus comatus significantly reduces its level. 8-Bromo-2'-deoxyguanosine finds applications in studies related to inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin inflammation.

Application

Products > Nucleoside, Nucleotide, Phosphoramidite > Nucleosides | Products > Nucleoside, Nucleotide, Phosphoramidite > Nucleosides > Halo-Modified

Product Information

• Catalog No.: BP-43562
• CAS No.: 13389-03-2
• Molecular Formula: C10H12BrN5O4
• Molecular Weight: 346.1
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source