Nutlin-3a

Overview

Nutlin-3a (Rebemadlin) is the active enantiomer of Nutlin-3 and is a potent inhibitor of murine double minute 2 (MDM2) with an IC50 of 90 nM. It disrupts the MDM2-p53 interaction, leading to stabilization of the p53 protein and subsequent induction of cell autophagy and apoptosis. Nutlin-3a is valuable for investigating TP53 wild-type ovarian carcinomas due to its structural specificity in targeting these interactions.

Application

Products > PROTAC, Molecular glue > Inhibitors

Product Information

• Catalog No.: BP-42116
• CAS No.: 675576-98-4
• Molecular Formula: C30H30Cl2N4O4
• Molecular Weight: 581.5
• Storage: -20°C
• Availability: In Stock

Source

Original product source