VH285-PEG4-C4-Cl

Overview

VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC 50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC 50 of 0.54 μM.

Application

Products | Products > Signaling Pathways > PROTAC | Products > Research Areas > Others | Products > Signaling Pathways > E3 Ligase Ligand-Linker Conjugates

Product Information

• Catalog No.: HY-111997
• CAS No.: 1799506-07-2
• Molecular Formula: C41H55ClN4O8S
• Molecular Weight: 799.42
• Purity: 96.49%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.13 mM); Clear solution
• Availability: In-stock

Source

Original product source