GNE-987

Overview

GNE-987 represents a PROTAC that combines ligands for von Hippel-Lindau and BRD4. It demonstrates highly potent cell BRD4 degradation activity at the picomolar level, and it features a robust BET binder/inhibitor, a fragment that binds to VHL, and a spacer moiety with ten methylene units. Additionally, GNE-987 holds applicability in PROTAC-Antibody Conjugate (PAC) approaches. Reagent-grade; for laboratory research purposes only.

Application

Products > PROTAC, Molecular glue > Degraders

Product Information

• Catalog No.: BP-41591
• CAS No.: 2417371-71-0
• Molecular Formula: C56H67F2N9O8S2
• Molecular Weight: 1096.3
• Storage: -20°C
• Availability: 24 Hours

Source

Original product source