HJB97

Overview

HJB97 is a high-affinity BET inhibitor with K i values of 0.9 nM ( BRD2 BD1 ), 0.27 nM ( BRD2 BD2 ), 0.18 nM ( BRD3 BD1 ), 0.21 nM ( BRD3 BD2 ), 0.5 nM ( BRD4 BD1 ), and 1.0 nM ( BRD4 BD2 ). HJB97 can serve as a ligand for target protein ( Ligands for Target Protein for PROTAC ) for the development of PROTAC BET degraders with antitumor activity. HJB97 can be used for the synthesis of BETd-260 ( HY-101519 ).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ligands for Target Protein for PROTAC | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-112429
• CAS No.: 2093391-24-1
• Molecular Formula: C26H28N8O3
• Molecular Weight: 500.55
• Purity: 99.12%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (4.99 mM); Clear solution
• Availability: In-stock

Source

Original product source