Mito-TEMPO

Overview

Mito-TEMPO is a mitochondria-targeted antioxidant. Mito-TEMPO induces mitophagy by activating the PINK1/Parkin pathway, inhibits NLRP3 inflammasome activation, restores mitochondrial membrane potential, and improves renal function and podocyte injury. Mito-TEMPO regulates Ca 2+ homeostasis, inhibits Bnip3 overexpression, shortens action potential duration, and exerts antiarrhythmic effects. Mito-TEMPO reverses premature senescence, reduces trabecular bone loss, and decreases cell apoptosis . Mito-TEMPO can be used in studies of chronic kidney disease, age-related cardiac dysfunction, postmenopausal osteoporosis, and ischemic stroke.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Cerebrovascular Disease | Products > Disease Areas > Mineral Metabolism | Products > Disease Areas > Renal Disease | Products > Disease Areas > Ischemic Stroke | Products > Disease Areas > Osteoporosis | Products > Disease Areas > Chronic Kidney Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > PINK1/Parkin | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-112879
• CAS No.: 1334850-99-5
• Molecular Formula: C29H35ClN2O2P
• Molecular Weight: 510.03
• Purity: 99.19%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution
• Availability: In-stock

Source

Original product source