Lithocholic acid 3-sulfate disodium

Overview

Lithocholic acid 3-sulfate disodium is a GPR39 agonist, with EC 50 values of 41 μM and 42.4 μM in M39-20 and hGPR39-2 cells, respectively, in the absence of Zn 2+ , and 0.88 μM and 0.97 μM in the presence of Zn 2+ . Lithocholic acid 3-sulfate disodium acts as a RORγt ligand. Lithocholic acid 3-sulfate disodium stimulates the GPR39 receptor to initiate intracellular calcium signaling, independent of the Zn 2+ -binding sites H17 and H19. LCA-3-S selectively inhibits Th17 cell differentiation by targeting RORγt. Lithocholic acid 3-sulfate disodium can be used in the research of cholestatic liver diseases.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Liver Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > GPR39 | Products > Signaling Pathways > ROR

Product Information

• Catalog No.: HY-113238A
• CAS No.: 64936-81-8
• Molecular Formula: C24H38Na2O6S
• Molecular Weight: 500.60
• Purity: 99.93%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source