Taurolithocholic acid-d 4

Overview

Taurolithocholic acid-d 4 is deuterium labeled Taurolithocholic acid. Taurolithocholic acid is an orally active bile acid and antiviral agent. Taurolithocholic acid upregulates FADS2 by activating the TGR5-PI3K/AKT-SREBP2 signaling axis, inhibits SFTSV -induced ferroptosis , viral replication and viral entry of HBV/HDV , while reducing the release of IL-1β , lipid ROS and LDH . While exerting antiviral protective effects, Taurolithocholic acid also stimulates the recycling of hepatocellular membrane transporters, impairs canalicular bile acid secretion function, and induces hepatocyte cholestasis, apoptosis and acute hepatocellular injury. Taurolithocholic acid serves as an experimental model compound for hepatocellular cholestasis. At concentrations ≤200 μM, Taurolithocholic acid shows no cytotoxicity and does not activate the interferon pathway. Taurolithocholic acid not only protects mice from lethal SFTSV infection but also is suitable for studies related to severe fever with thrombocytopenia syndrome and cholestasis.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Others | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Research Areas > Others | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Akt | Products > Signaling Pathways > HBV

Product Information

• Catalog No.: HY-113308S1
• CAS No.: 2410279-96-6
• Molecular Formula: C26H41D4NO5S
• Molecular Weight: 487.73
• Purity: 98.36%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source