3-Methylglutaric acid -d 4 is the deuterium labeled 3-Methylglutaric acid ( HY-113410 ). 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na + , K + -ATPase , with an inhibition rate of 30% on rat cortical synaptosomal Na + , K + -ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration.
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