RO2959 monohydrochloride

Overview

RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC 50 of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC 50 of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways.

Application

Products | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > CRAC Channel | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-113618B
• CAS No.: 2309172-44-7
• Molecular Formula: C21H20ClF2N5OS
• Molecular Weight: 463.93
• Purity: 98.03%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: 2.5 mg/mL (5.39 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source