ABT-255 free base is an orally active anti- bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin ( HY-B0272 )- or Ethambutol ( HY-B0535 )-resistant Mycobacterium tuberculosis . ABT-255 free base shows efficacy against S. aureus , S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis.
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