VUF5834 is a non-peptide chemokine receptor CXCR3 antagonist with non-competitive antagonistic and inverse agonistic activities. VUF5834 blocks the effects of CXCL10 and CXCL11 on human CXCR3 , exhibits non-competitive antagonistic and inverse agonistic properties to CXCR3 , and, except for TAK-779, has a slightly lower affinity for rodent CXCR3 than for primate CXCR3 .
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