Azumolene sodium (EU4093) is an analog of Dantrolene ( HY-12542 ) that inhibits malignant hyperthermia (MH) syndrome and intracellular Ca 2+ homeostasis failure caused by Halothane (HY-B1010)/Succinylcholine. Azumolene sodium (0.5-2.0 mg/kg) reduces [Ca 2+ ]i (from 207 nM to 38 nM) in MH-susceptible skeletal muscle following intramuscular injection.
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