TAK-070 hydrochloride hydrate is a noncompetitive and orally active BACE1 inhibitor ( IC 50 = 3.15 μM). TAK-070 hydrochloride hydrate can be used for research of Alzheimer’s disease (AD). TAK-070 hydrochloride hydrate inhibits brain levels of soluble Aβ , and improves cognitive impairments in AD model.
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