cis-VZ185 serves as a non-degradative control and inactive analog of VZ185 ( HY-114322 ), a dual-target BRD7 / BRD9 degrader PROTAC . cis-VZ185 exerts antiproliferative activity against epithelioid sarcoma cells only at high concentrations. cis-VZ185 induces morphological changes in osteosarcoma cells. cis-VZ185 can be used in studies related to epithelioid sarcoma. (Pink: BRD9 and BRD7 ligand ( HY-111905A ); Blue: VHL ligand ( HY-176302 ); Black: linker).
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs
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