GNE-8505

Overview

GNE-8505 is an orally active, blood-brain barrier-permeable selective dual leucine zipper kinase ( DLK ) inhibitor. GNE-8505 has an IC 50 of 0.144 μM for pJNK , and EC 50 of 0.457 μM for DRG . GNE-8505 inhibits the DLK / JNK pathway, reduces stress-induced c-Jun phosphorylation levels, decreases neuronal death and suppresses axonal degeneration. GNE-8505 reduces phosphorylated c-Jun levels in the retina, spinal cord and brain tissues of mice. GNE-8505 is applicable to research related to Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Obesity | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > MAP3K | Products > Signaling Pathways > JNK

Product Information

• Catalog No.: HY-114332
• CAS No.: 1620573-48-9
• Molecular Formula: C21H24F3N5O
• Molecular Weight: 419.44
• Purity: 99.53%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source