TD-428

Overview

TD-428 is a PROTAC connected by ligands for Cereblon and BRD4 . TD-428 is a highly specific BRD4 degrader with a DC 50 of 0.32 nM. TD-428 is a BET PROTAC , which comprises TD-106 (a CRBN ligand) linked to JQ1 (a BET inhibitor). TD-428 efficiently induce BET protein degradation. (Pink: BRD4 ligand ( HY-78695 ); Blue: Cereblon ligand ( HY-114406 ); Black: linker).

Application

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Product Information

• Catalog No.: HY-114407
• CAS No.: 2334525-50-5
• Molecular Formula: C43H43ClN10O7S
• Molecular Weight: 879.38
• Purity: 98.81%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source