FKBP12 PROTAC dTAG-13

Overview

FKBP12 PROTAC dTAG-13 (dTAG-13) is a FKBP12 F36V PROTAC degrader and a PXR partial agonist. FKBP12 PROTAC dTAG-13 induces ubiquitination and proteasomal degradation of proteins tagged with FKBP12 F36V , without degrading wild-type FKBP12 or un-fused PXR . It weakly promotes the recruitment of SRC-1 , strongly inhibits the interaction between NCoR and PXR , and upregulates the expression of CYP3A4 and other drug metabolism-related genes. FKBP12 PROTAC dTAG-13 is applicable to research related to breast cancer and leukemia [1] . (Pink: FKBP12F36V ligand ( HY-114420 ); Blue: Cereblon ligand ( HY-103596 ); Black: linker).

Application

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Product Information

• Catalog No.: HY-114421
• CAS No.: 2064175-41-1
• Molecular Formula: C57H68N4O15
• Molecular Weight: 1049.17
• Purity: 99.89%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.38 mM); Clear solution
• Availability: In-stock

Source

Original product source