TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI , TRADD , and RIP1 , the EC 50 values for TNFα , IL-1β , and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β .
Products | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Others | Products > Signaling Pathways > IKK | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > RIP kinase
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