Pyridoxal isonicotinoyl hydrazone

Overview

Pyridoxal isonicotinoyl hydrazone is an orally active and lipophilic iron-specific chelator that acts as a non-competitive inhibitor of ferrochelatase ( FECH ) by binding iron ions. Pyridoxal isonicotinoyl hydrazone disrupts heme biosynthesis, leading to reduced FECH stability and increased protoporphyrin IX (PPIX) accumulation. Pyridoxal isonicotinoyl hydrazone is promising for research of iron-overload diseases (e.g., β-thalassemia).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Biochemical Assay Reagents | Products > Signaling Pathways > Ferrochelatase

Product Information

• Catalog No.: HY-114758
• CAS No.: 737-86-0
• Molecular Formula: C14H14N4O3
• Molecular Weight: 286.29
• Purity: 99.96%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 1.47 mg/mL (5.13 mM); Clear solution
• Availability: In-stock

Source

Original product source