VU0424465

Overview

VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu 5 mediated iCa 2+ mobilization. VU0424465 exhibits high affinity at MPEP allosteric binding site, with a K i value of 11.8 nM. VU0424465 is also a agonist for pERK1/2 in cortical neurons.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > mGluR | Products > Signaling Pathways > PERK

Product Information

• Catalog No.: HY-114978
• CAS No.: 1428630-85-6
• Molecular Formula: C19H19FN2O2
• Molecular Weight: 326.36
• Purity: 99.84%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (15.32 mM); Clear solution
• Availability: In-stock

Source

Original product source