15-deoxy-Δ12,14-Prostaglandin D2

Overview

15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 ( HY-101988 ), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation ( EC 50 =8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 ( SRC-1 ) to peroxisome proliferator-activated receptor γ ( PPARγ ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells ( IC 50 =0.3 μg/ml) and inhibits ADP-induced platelet aggregation ( IC 50 =320 ng/mL).

Application

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Product Information

• Catalog No.: HY-116028
• CAS No.: 85235-11-6
• Molecular Formula: C20H30O4
• Molecular Weight: 334.45
• Purity: 98.0%
• Storage: Solution, -20°C, 2 years
• Availability: In-stock

Source

Original product source