MAGL-IN-12

Overview

SAR127303 is an orally active, selective, competitive monoacylglycerol lipase ( MAGL ) covalent inhibitor with IC 50 s of 3.8 nM and 29 nM for mouse and human MAGL , respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > MAGL

Product Information

• Catalog No.: HY-116143
• CAS No.: 1352011-38-1
• Molecular Formula: C16H17ClF6N2O4S
• Molecular Weight: 482.83
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source