ML-184 (CID244033) is a selective GPR55 agonist with an EC 50 of 250 nM, more than 100-fold selectivity for GPR55 over GPR35 , CB1 , and CB2 . ML-184 induces ERK1/2 phosphorylation and PKCβII translocation to the plasma membrane via activation of GPR55 . ML-184 (CID2440433) increases the proliferation of neural stem cells and promotes neuronal differentiation in vitro.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > GPR55
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