Prothioconazole

Overview

Prothioconazole is an orally active broad-spectrum fungicide. Prothioconazole weakly inhibits CaCYP51 activity in Candida albicans , with an apparent IC 50 of approximately 120 μM. Prothioconazole disrupts Microtubule stability by reducing the acetylation level of α-tubulin. Prothioconazole induces Mitochondrial dysfunction , oxidative stress, DNA damage, and Apoptosis . Prothioconazole accumulates 14 -methylated sterols and depletes ergosterol in cells, culture media, plants , and animals . Prothioconazole interferes with pyruvate metabolism and glycolysis/gluconeogenesis processes in mouse liver, downregulates Fasn mRNA expression, and induces hepatotoxicity and renal metabolic disorders. Prothioconazole reduces the fertility of female mice. Prothioconazole inhibits body weight gain and increases liver/kidney indices in mice. Prothioconazole can be used in studies related to candidiasis.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Fungal Infection | Products > Disease Areas > Renal Disease | Products > Disease Areas > Female Reproductive System Disease | Products > Disease Areas > Hepatotoxicity | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Infection | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Mitochondrial Metabolism | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Fatty Acid Synthase (FASN) | Products > Signaling Pathways > Fungal | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Microtubule/Tubulin

Product Information

• Catalog No.: HY-116568
• CAS No.: 178928-70-6
• Molecular Formula: C14H15Cl2N3OS
• Molecular Weight: 344.26
• Purity: 99.52%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.26 mM); Clear solution
• Availability: In-stock

Source

Original product source