Amorphigenin

Overview

Amorphigenin is a trothotenone compound. Amorphigenin inhibits osteoclast differentiation by suppressing the expression of c-Fos and NFATc1 in activated T cells. Amorphigenin degrades melanosome proteins by activating the AMPK -dependent autophagy pathway, but not in dependence of the mTOR pathway. Amorphigenin significantly protects bone mass and reduces bone erosion in a mouse model of inflammatory bone loss. Amorphigenin can be used to study inflammatory bone diseases, postmenopausal osteoporosis, and skin pigmentation disorders.

Application

Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Autophagy | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Endocrinology | Products > Signaling Pathways > AP-1 | Products > Signaling Pathways > Nuclear Factor of activated T Cells (NFAT) | Products > Signaling Pathways > AMPK | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-116640
• CAS No.: 4208-09-7
• Molecular Formula: C23H22O7
• Molecular Weight: 410.42
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source