Lobaric acid

Overview

Lobaric acid is a depsipeptide metabolite isolated from Stereocaulon lichen with antioxidant, antiproliferative, antiviral and enzyme inhibitory activities. Lobaric acid scavenges superoxide free radicals ( IC 50 =97.9 μM) and inhibits cancer cell proliferation ( EC 50 of 15.2-63.9 μg/mL against leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic and lung cancer cell lines). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC 50 =0.87 μM for human recombinant enzyme) and 12(S)-HETE produced by 12(S)-lipoxygenase ( IC 50 =28.5 μM). Lobaric acid (250 μM) also reduced pathological changes in tobacco leaves infected with tobacco mosaic virus ( TMV ).

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > Lipoxygenase | Products > Signaling Pathways > TMV

Product Information

• Catalog No.: HY-117085
• CAS No.: 522-53-2
• Molecular Formula: C25H28O8
• Molecular Weight: 456.49
• Purity: 95.2%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source