Necrostatin-7

Overview

Necrostatin-7 (Nec-7) is a Necroptosis inhibitor with an EC 50 of 10.6 μM. Necrostatin-7 inhibits signal transduction from RANK to NFATc1 without affecting the activation of MAPK or NF-κB . Necrostatin-7 suppresses the expression levels of Acp5 , Atp6v0d2 , Ctsk and Dcstamp . Necrostatin-7 reduces myocardial infarction size, ameliorates adverse left ventricular remodeling, decreases myocardial wall stress, reduces the amount and length of scar tissue, and improves left ventricular function. Necrostatin-7 exerts cardioprotective effects in a rat model of permanent coronary artery occlusion. Necrostatin-7 can be used in research related to osteolytic bone diseases and myocardial infarction.

Application

Products | Products > Disease Areas > Myocardial Infarction | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Heart Disease | Products > Disease Areas > Osteogenic Differentiation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Necroptosis | Products > Signaling Pathways > RANKL/RANK

Product Information

• Catalog No.: HY-117200
• CAS No.: 351062-08-3
• Molecular Formula: C16H10FN5OS2
• Molecular Weight: 371.41
• Purity: 99.64%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source